Preparation of Nano Magnesium Oxide Loaded with Syrian Inula Plant Extract And Study of antibacterial activity Against Vibrio cholera

Abdulrazzaq Hammal; Hiba  Al-Hamed Al-Duihi

doi:10.35192/jjoas-n.v17i2.1072

Abdulrazzaq Hammal Department. of Basic Science-chemistry, College of electrical engineering, University of Aleppo_ Syria.
Hiba Al-Hamed Al-Duihi Department. of Microbiology, Faculty of Pharmacy, Hamma University, Hamma_ Syria

DOI: https://doi.org/10.35192/jjoas-n.v17i2.1072

Abstract

Background: Nanotechnology is considered one of the best advanced technologies in treatment through its ability to transport effective drugs and compounds and release them more effectively. MgO nanoparticles showed antimicrobial properties against both Gram-negative and Gram-positive bacteria in vitro, including Escherichia coli and Staphylococcus aureus, as Vibrio cholera bacteria was selected during the period when the epidemic began to appear in Syria, with the presence of several people showing symptoms of diarrhea in the city of Aleppo.

Methods: In this research, Nano magnesium oxide particles were prepared by sol-gel method, then the active compounds were extracted from the Syrian Inula plant using ethanol as a solvent. next step was load the plant extract on the surface of the prepared magnesium oxide particles. The antibacterial activity of the new product was studied against the bacteria that cause cholera.

Results: Its effectiveness was compared with the effectiveness of 7 different antibiotics, and it outperformed all of them, noting that the studied isolate was resistant to three of them.

Conclusion: The combination of nanoparticles with the natural extract is more effective in fighting bacteria, because each of them works in a different way and affects differently, so the combination of the two technologies gives greater effectiveness.

Keywords: Inula, Nanomagnesium oxide, Vibrio cholera.